Let R be a semiprime ring. A mapping F on R is said to be a multiplicative generalized semiderivation of R if there exists a multiplicative semiderivation d associated with a map g on R such that (i) F(xy) =F(x)y + g (x) d(y) = d(x)g (y) + xF(y) and (ii) F(g(x)) = g(F(x)), for all x, y ∈ R. The purpose of this paper is to study multiplicative generalized semiderivations satisfying certain differential identities on semiprime rings.