The aim of this paper is to establish a relationship between soft sets and Γ-semihypergroups. In this aspect, we have introduced soft intersection generalized interior Γ-hyperideals and soft intersection generalized bi-Γ-hyperideals of Γ-semihypergroups with some interesting examples. Moreover, we study some characterizations of regular, intraregular, semisimple and right weakly regular Γ-semihypergroups in terms of soft intersection generalized interior Γ-hyperideals and soft intersection generalized bi-Γ-hyperideals.