Let $G= (V,E)$ be a $(p,q)$-graph. A bijection $f: Eto{1,2,3,ldots,q }$ is called an edge-prime labeling if for each edge $uv$ in $E$, we have $GCD(f^+(u),f^+(v))=1$ where $f^+(u) = sum_{uwin E} f(uw)$. Moreover, a bijection $f: Eto{1,2,3,ldots,q }$ is called a semi-edge-prime labeling if for each edge $uv$ in $E$, we have $GCD(f^+(u),f^+(v))=1$ or $f^+(u)=f^+(v)$. A graph that admits an  edge-prime (or a semi-edge-prime) labeling is called an edge-prime (or a semi-edge-prime) graph. In this paper we determine the necessary and/or sufficient condition for the existence of (semi-) edge-primality of many family of graphs.